In the crystal, the decamer forms B-DNA double helices with characteristic groove dimensions: compared with B-DNA of random sequence, the minor groove is ...
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Does B-DNA have major and minor grooves?
What is the minor groove of the DNA helix?
Can drugs or polypeptides bind to either the minor or major groove of DNA?
What is the double helical structure of B-DNA?
Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein–DNA and 14 drug–DNA complexes.
A new definition is presented for minor-groove width in double-helical B-DNA structures. This uses interstrand H4′…H5′ rather than P…P distances.
In these complexes, the drug molecules bind to the central AT segment (4–6 base pairs long) in the narrow minor groove of the dodecamer B-DNA double helix.
-. Basic information ; Journal: Nat.Struct.Biol. / Year: 1994. Title: Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex.
... double helix, and another in which it is buried deep within the minor groove. Steric clash between the drug and DNA dictates that the phenol-benzimidazole ...
Mar 1, 1994 · The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides ...
Abstract. The geometry of the hydrogen bonding interaction between DNA and minor-groove binding drugs has been analyzed from a sample of 22 crystal structu.
The double helix structure of DNA contains a major groove and minor groove. In B-DNA the major groove is wider than the minor groove. Given the ...
3. The narrowness of the B-DNA minor groove in A+T-rich regions (25) forces the drug molecule to sit squarely in the center of the groove, with each of its ...